Late last year, I released a simple plugin to add SASS/SCSS capabilities to WordPress. I was fairly disappointed with the result since the stylesheet compiler I was using (PHamlP) had some serious flaws and was abandoned in Sept, 2010. However, thanks to a recent comment by zoombody, I became aware of a new stylesheet compiler which shows some real promise.
Thus, I have just released a new version of the plugin which employs phpsass. It also now automatically enqueues the compiled stylesheet. If you want to give SASS a try, try out this simple tutorial, install the plugin and see what you can create.